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Prostate Problem Guide

Advanced Prostate Cancer - Options For Treatment

Prostate cancer normally develops within the peripheral area of the prostate gland and this initially small area of cancerous tissue cannot be felt on a digital rectal examination (DRE) but is often picked up through a PSA test or an ultrasound examination. At this point prostate cancer is described as being in Stage I or is described as a T1 cancer.

As the cancerous region grows within the prostate it will create abnormalities which can now be felt during a DRE and, at this point, the disease is said to have progressed to Stage II or become a T2 cancer.

In both Stage I and Stage II cancer is confined to the prostate gland and is normally treated surgically, with radiation therapy, with cryosurgery or using ultrasound.

As the cancer continues to grow it will spread into surrounding tissues within the pelvic area and will move into Stage III or be classed as a T3 cancer. Finally, prostate cancer cells will be carried to regions of the body outside of the pelvic area and prostate cancer reaches Stage IV or becomes a T4 cancer. It is these two stages of the disease that are classed as being "advanced prostate cancer".

The treatment of advanced prostate cancer is aimed principally at slowing the spread of the disease, providing the best possible quality of life for the patient and extending the patient's life as far as is possible. Although it is possible to cure prostate cancer, particularly in Stage III, the advanced nature of the disease makes this a difficult task and the reality of the situation is that treatment at this point generally represents management of the disease rather than a cure for it.

As prostate cancer cells require male hormones (such as testosterone) to grow, the main form of treatment for advanced prostate cancer is hormone treatment to reduce the production of testosterone.

Hormone therapy may include the use of drugs to reduce testosterone levels in the body or to block the action of testosterone and other male hormones. Treatment options will also include the removal of the testicles (orchiectomy) which produce 95% of the testosterone found in the body.

In some cases of Stage IV cancer hormone therapy may not be effective, or may have only limited results, and patients may require systematic radiation therapy or chemotherapy.

Further information on advanced prostate cancer treatment:

Presence of AR-V7 in Circulating Tumor Cells Validated as Predictive Biomarker for Advanced Prostate Cancer ... - PR Newswire (press release)


Presence of AR-V7 in Circulating Tumor Cells Validated as Predictive Biomarker for Advanced Prostate Cancer ...
PR Newswire (press release)
This discovery, published today in JAMA Oncology, emerged from a study of 161 progressing metastatic castration-resistant prostate cancer (mCRPC) patients about to start an FDA approved ARSIs or taxane as a first, second or third line treatment at ...

and more »

Advanced Prostate Cancer: Ways To Control Symptoms Of Incurable Disease - Health Aim


Advanced Prostate Cancer: Ways To Control Symptoms Of Incurable Disease
Health Aim
Advanced prostate cancer occurs when the disease has spread outside the prostate gland to other parts of the body, including the bones. This stage of prostate cancer is incurable, but there are available treatments that can potentially help patients ...

and more »

Scientists Identify Biomarker for Advanced Prostate Cancer as Specific Androgen Receptor in Circulating Cancer Cells - Prostate Cancer News Today


Prostate Cancer News Today

Scientists Identify Biomarker for Advanced Prostate Cancer as Specific Androgen Receptor in Circulating Cancer Cells
Prostate Cancer News Today
Furthermore, AR-V7-positive patients were found to survive for longer periods when treated with taxane-based chemotherapy instead of ARS inhibitors. “This study indicates the potential for an AR-V7 predictive test to enable advanced prostate cancer ...

Apalutamide Investigated in High-Risk Prostate Cancer - Targeted Oncology


Targeted Oncology

Apalutamide Investigated in High-Risk Prostate Cancer
Targeted Oncology
Researchers are hoping the results of a latestage efficacy and safety study of apalutamide (ARN-509) in patients with high-risk, localized, or locally advanced prostate cancer who are receiving primary radiation therapy will demonstrate an improvement ...